Sieve analysis

Particle size has an impact on many pharmaceutical properties such as solubility, compressibility, and bioavailability. From the discovery phase to formulation, quality control and final stage of manufacture, sieve analysis is one of the most widely used analytical procedures for assessing particle size and particle size distribution due to its ease of use and accuracy.

Fine powders, and especially powders with a particle size of less than 40 µm, have been shown to be prone to static electricity, agglomeration, and clogging of the sieve during the screening process. The classic vibrating sieving equipment has proven difficulty in sieving fine powders quickly and accurately, making it ineffective. However, with an air jet sieve, maximum effectiveness is achieved due to the strong shearing force induced by air flow.

Air jet sieving uses stream of air to move particles through a sieve mesh. The vacuum controlling the pressure decrease in the sieve chamber causes the particles to be dispersed and deagglomerated on the sieve cloth briefly before being sucked through the mesh. As a result, the coarse material remains on the sieve, while the fine material is sucked by the vacuum. Advantages of the analysis include the ease of operation, costs and accuracy, as well as no prior sample preparation is required. The method is suited for dry powder materials.

Air jet sieving is an important method of quality control of fine bulk pharmaceutical materials. Sieving analysis with possible variations of sieving parameters in combination with other analytical techniques that we offer at Particle Analytical prove to be beneficial to our customers providing reliable results.

Instrument

Air Jet Sieve E200 LS

USP/Ph.Eur.

USP 786/ Ph. Eur. 2.9.38

Measurement range (with ø 200 / 203 mm)

20 µm to 4 mm

Vacuum pressure

1500-4000 Pa

Air flow rate

70-130 m3/h

Sample amount

10-100 g

Consult our Experts

Dr. Wenbo Wang
QC Chemist

Dr. Anna Shevchenko
Principal Scientist

Literature

Adjei A, Garren J (1990) Pulmonary delivery of peptide drugs: effect of particle size on the bioavailability of leuprolide acetate in healthy male volunteers. Pharm Res (6):565-9.

Barber D, Keuter J, Kravig K. A logical stepwise approach to laser diffraction particle size distribution analysis methods development and validation. Pharmaceutical development and technology. 1998 Jan 1;3(2):153-61. 

Buanz A (2021) Powder characterisation. In The Science and Practice of Pharmacy, ed. Adejare A, Remington: 295-305.

Kumar R, Thakur AK, Chaudhari P, Banerjee N ( 2021) Particle Size Reduction Techniques of Pharmaceutical Compounds for the Enhancement of Their Dissolution Rate, and Bioavailability. J Pharm Inno 11:1-20.

Provder T. Challenges in particle size distribution measurement past, present and for the 21st century. Progress in organic coatings. 1997 Dec 1;32(1-4):143-53.sperser. Int J Pharm 501(1-2):65-74.

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