Hot Stage Microscopy is a unique method in “trapping” polymorphic forms during heating. The current example (click to watch the film) shows how an API goes through several polymorphic transformations during heating (and cooling). Just prior to melting a newpolymorph form, consisting of needles, appears. Without the use of Hot Stage Microscopy this polymorphic form could easily have been overlooked, as the energetic changes connected to the transformation would have been masked by melting in a DSC experiment. The picture below is another example of a transformation taking place after melting/cooling. A quite fascinating formation!
If such an experiment could be relevant for your API in search for new polymorphic forms, do not hesitate to contact us.