BET Analysis
Specific surface area determination by gas adsorption (BET)
Specific surface area determination by gas adsorption (BET)
The method BET (Brunauer-Emmett-Teller) evaluates both outer and inner surface area of powders since the small gas molecules can reach even very small pores and cracks. BET analysis is a critical method for measuring the surface area of pharmaceutical powders, as well as the volume and size distribution of nanopores.
These properties can directly affect drug dissolution rates, adsorption, content uniformity, fine dose and overall formulation performance.
At Particle Analytical, we conduct BET analysis using the Micromeritics Gemini VII The instrument provides measurements of specific surface area (m²/g), along with volume and size distribution of nanopores in compliance with Ph. Eur. 2.9.26 II.
How Particle Analytical can assist with BET Analysis
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Specific Surface Area Measurement for Characterization
Accurately measures the surface area of pharmaceutical powders, which impacts drug product performance attributes and quality of active drug ingredients, including fine-particle fraction (FPF), or the fine-particle dose (FPD) of dry inhalation products, as well as dissolution rates and bioavailability of oral products -
Nanopore Volume and Size Distribution
Provides detailed insights into the volume and distribution of nanopores, influencing the adsorption properties of materials. -
Formulation Optimization
Helps optimize drug formulations by analyzing surface area and porosity, critical for enhancing drug absorption, even content uniformity, stability and efficacy. The specific surface area was shown to be a vital quality attribute for development of dry inhalation formulations. -
Quality Control Support
Being a crucial quality attribute, this property ensures consistent surface area and porosity across production batches, supporting regulatory compliance and maintaining product quality. -
Material Characterization
Offers insights into how surface properties affect the behavior of excipients and active pharmaceutical ingredients (APIs), aiding in the development of stable and effective formulations.
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