Dynamic Vapor Sorption (DVS)
Surface Area Expertise
What is Dynamic Vapor Sorption (DVS) ?
DVS is a powerful technique for measuring how pharmaceutical materials interact with moisture or solvent vapors across different humidity and temperature conditions.
These interactions are key for assessing stability, hygroscopicity, and the influence of moisture on formulations and active pharmaceutical ingredients (APIs).
At Particle Analytical, we offer DVS analysis using two complementary systems:
- TA Instruments Discovery SA – a GMP-qualified system for validated analysis.
- SMS Advantage 1 – available for non-GMP studies, offering a video imaging option for visual observation of material changes during sorption.
Both systems operate from 5°C to 85°C, across 0–98% relative humidity, and support testing with water or organic solvent vapors. The TA system is fully compliant with Ph. Eur. 2.9.39.
How Particle Analytical can assist with DVS
Sorption Isotherm Measurement
We measure the uptake and release of water or solvents at controlled humidity levels to assess hygroscopicity and solvent interactions – essential for selecting the optimal solid-state form.
Quantification of Amorphous Content in API
Differences in vapor uptake between amorphous and crystalline fractions enable us to develop methods for quantifying amorphous content. The use of organic solvent vapors enhances both sensitivity and robustness.
Stability Assessment
Evaluate how materials respond to moisture over time to support stability studies and packaging selection.
Formulation Development
Understand material-environment interactions to design moisture-robust formulations with improved shelf-life.
Temperature and Humidity Control
Customizable testing conditions using full control of RH and temperature, from 5°C to 85°C and 0–98% RH.
Quality Control Support
GMP-compliant DVS analysis supports batch-to-batch consistency, regulatory compliance, and release testing.
Video Imaging Option (SMS only)
Our non-GMP SMS system includes a video imaging feature, allowing visual monitoring of physical changes during sorption for deeper insights during early development.
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By choosing Particle Analytical, you get a strong and specialized partner, with a wide range of analysis, scalable and flexible services, and strong accreditations.