Hot Stage Microscopy
Material analysis under temperature variations
Hot Stage Microscopy (HSM)
Hot Stage Microscopy (HSM) is a powerful technique used to visually observe the behavior of pharmaceutical materials as they are heated. It provides valuable insights into phase transitions, melting points, and crystallization processes.
At Particle Analytical, we utilize the Línkam FTIR600 which captures microscope images during heating.With a temperature range from 25°C to 375°C and precise humidity control from 5-90% RH – our system delivers detailed visual and thermal analysis of pharmaceutical materials under controlled environmental conditions. This system in combination with Raman microscopy gives the spectroscopic support to conclusions made based on visually observed changes.
How Particle Analytical can assist with Hot Stage Microscopy (HSM)
Phase Transition Analysis
Visually observes phase transitions such as melting, crystallization, or polymorphic changes during heating, providing critical data for formulation development.
Temperature and Humidity Control
Monitors material behavior under varying temperature and humidity, essential for stability studies and predicting real-world performance.
Crystallization Studies
Helps assess crystallization behavior under controlled conditions, aiding in the selection of stable crystalline forms for drug formulations.
Formulation Development
Supports the optimization of formulations by providing real-time insights into how materials behave under thermal stress.
Quality Control Support
Ensures that materials exhibit expected thermal behavior, helping to maintain consistency and compliance across batches.
Please pick a subject
How we can help
Learn more about How we can help you addressing problems in your development or manufacturing process, by applying our strong technical and analytical skills.
Knowledge Hub
Explore our Knowledge Hub for regulatory guidelines, publications, events and FAQ, that bring you insights into particle analysis
Why choose us
By choosing Particle Analytical, you get a strong and specialized partner, with a wide range of analysis, scalable and flexible services, and strong accreditations.