X-ray Powder Diffraction (XRPD)
Get insights into the crystalline structure of compounds
X-ray Powder Diffraction (XRPD)
X-ray Diffraction (XRPD) is essential for investigating the crystalline structure of pharmaceutical materials. It is a golden standard method for study polymorphism, crystallinity, and phase identification – key for drug formulation and stability.
At Particle Analytical, we perform XRD services using the PANalytical X’Pert3 Powder XRD and Empyrean XRD – equipped with a climate chamber, micro-CT and Bragg-Brentano optical module.
How Particle Analytical can assist with XRPD
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Polymorphism Identification
Best known method to differentiate between polymorphic forms of drug substances, ensuring the most stable and effective form is selected for development. -
Counterfeit analysis
Fake or falsified medicine can be identified by aid of XRD analysis, since the registered drug product will have specified XRD diffraction pattern. -
Crystallinity Determination
Measures the degree of crystallinity, which directly impacts solubility, bioavailability, and stability of pharmaceutical materials. -
Phase Identification
Detects and characterizes crystalline phases to ensure consistency across batches and maintain quality control. -
Stability Testing
Empyrean XRD’s climate chamber enables creation of stress atmosphere so that it is possible to investigate temperature and humidity induced transitions to reveal possible stability issues in APIs and drug products. -
Crystallite Size and Strain Analysis
Evaluates crystallite size and internal strain, factors that influence the performance of pharmaceutical products. -
Quantitative Phase Analysis
Provides data on the exact amount of each phase in the mixture, including ratio of crystalline to amorphous phases, critical for product development and regulatory compliance. -
Formulation Compatibility
The consistency and stability of the physical form (salt, cocrystal, polymorphic from, amorphous form) of API in the formulation is crucial for drug product quality, safety and efficacy. The compatibility analysis assisted with XRD will reveal all possible changes due to ingredient incompatibility and give a valuable data to select safe excipients that will not decrease chemical or physical stability of API. -
Structural Analysis via Micro-CT
The micro-CT module enables three-dimensional imaging, offering detailed visualization of the internal structure of pharmaceutical products. -
Quality Control Support
Ensures batch-to-batch consistency, detects impurities, and supports compliance with regulatory standards throughout manufacturing.
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