Polymorph screening reveals three forms

A basic polymorph screening were performed on a well known compound.  A “wet part” were prepared in three solvents with very different properties: Water, ethanol and hexane (at different temperatures and evaporation rates). 

In water, a hydrate forms was formed (needle shaped) and in ethanol a mixture between the starting material and a new form was obtained. Dissolution in hexane lead to formation of amorpheous material. Thus, a very simple set-up reveals 4 forms. Further studies will include development of the “pure form” of the polymorph only seen in mixture – and attempt to isolate more polymorphic forms by heating the amorpheous form.