Thermogravimetric Analysis (TGA)
Measures the amount of weight change
Thermogravimetric Analysis (TGA)
Thermogravimetric Analysis (TGA) offers precise insights into the thermal stability and compositional changes of pharmaceutical compounds, ensuring high-quality and reliable products.
TGA is a thermal analysis technique that measures the amount of weight change in a material as a function of temperature or time.
Thermogravimetric Analysis is essential for characterizing materials that exhibit weight loss upon heating, such as pharmaceutical compounds, to determine stability, content of volatiles, and decomposition points.
How Particle Analytical can assist with TGA
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Thermal Stability Assessment
Determines the temperature at which substances begin to decompose or lose the solvent of crystallization, providing insights into material stability. Together with other thermal analytical methods (link to DSC and HSM) helps to evaluate nature and properties of different solid-state forms to enable solid-form selection process. -
Composition Monitoring
Tracks changes in composition across temperature ranges, aiding in the detection of degradation, decomposition, and desolvation. -
Moisture Content Analysis
Measures moisture levels and identifies processes such as evaporation or absorption, which can impact material quality and stability. -
Volatiles Analysis
Quantifies volatile components that may affect material properties and overall stability. -
Purity Verification
Detects impurities and measures their concentrations, ensuring the purity of pharmaceutical materials. -
Degradation Kinetics
Analyzes the rate of thermal decomposition, offering insights into degradation processes over time. -
Excipients Characterization
Assesses the thermal behavior and compatibility of excipients with other formulation components to ensure product stability. -
Quality Control Support
Ensures materials meet required criteria for stability, purity, and composition during production.
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