Production and supplier comparison

When comparing solid powders from different suppliers, understanding their solid-state properties is crucial for achieving consistent product performance.

Key properties to evaluate

• Flowability

  Smooth manufacturing and uniform dosage rely on how easily the powder flows through equipment. Poor flowability can lead to manufacturing issues, such as dosage inconsistencies and processing delays.

• Compaction Behavior

  The ability of a powder to form stable tablets or other solid forms is essential for ensuring product integrity. Variations in compaction behavior can affect the hardness, disintegration time, and overall quality of the final product.

• Surface Area

  The surface area of a powder influences its dissolution rate and, consequently, its bioavailability. A higher surface area can enhance the rate at which a drug is absorbed, impacting its effectiveness and therapeutic outcomes.

• Identification by XRD (X-ray Diffraction)

  Ensuring that the correct crystalline form is present is critical for regulatory compliance and product stability. Different crystalline forms can have varying solubility, stability, and bioavailability, making accurate identification essential.

• Particle Sizing

  Consistent particle size distribution is key to ensuring uniformity in the final product. Variations in particle size can lead to differences in drug release profiles, affecting the efficacy and safety of the product.

• Morphology

  The shape and surface features of particles, analyzed through microscopy, can significantly impact how powders mix, flow, and compress. Understanding morphology is crucial for optimizing processing and achieving desired product characteristics.