Introduction to dissolution rate measurements
The dissolution rate is a measure of the actual release rate of the compound at the given particle size etc. in an aqueous media. It often vary considerably with solid form, e.g. particle size and shape (read more about dissolution theory). Dissolution tests are used for:
- Ensuring that production processes are under control.
- Evaluating of the developability of a compound: Does the dose at the given particle size dissolve in vivo? This can be tested by examining the dissolution rate in different solvents, mimicing the biological conditions (pH 1-8 ).
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Instrument and measuring principle
The dissolution test equipment applied by Particle Analytical is a Vankel Dissolution Sampling Station. The concentrations are determined on a Varian UV-VIS spectrometer. The default solvent volume is 900 ml unless otherwise stated. Samples are withdrawn at welldefined intervals and filtrated before concentration determination.
|Instrument||Vankel VK8000 Dissolution Sampling Station|
|Sample amount||Depends on purpose (dissolution of tablet or powder – sink conditions). Max solvent volume: 900 ml|
|Stirring rates||50 or 100 RPM|
|Result||Reported as curve showing concentration over time (min)|