Dissolution rate measurements

Slide

The dissolution rate is a measure of the actual release rate of the compound at the given particle size etc. in an aqueous media. It often varies considerably with solid form, e.g. particle size and shape (read more about dissolution theory). The rate of dissolution is of major importance in regard to the behaviour of the compound in vivo.  

Dissolution tests are used for: 

  • Ensuring that production processes are under control 
  • Formulation development: comparison of effect of different formulation on product performance 
  • Evaluation of the effect of different particle size batches on the dissolution 

For Material experts: 

Instrument and measuring principle 

The dissolution test equipment applied by Particle Analytical is a Vankel Dissolution Sampling Station. The concentrations are determined on a Varian UV-VIS spectrometer. The default solvent volume is 900 ml unless otherwise stated. The apparatus is equipped with a fibre optic sensor. 

WHAT TYPE OF APPARATUS 

Instrument Vankel VK7000 /Versa Fiber optics 
USP/Ph. Eur. USP 〈711〉 /Ph.Eur. 2.9.3 (non-GMP)
Sample amount Depends on purpose (dissolution of tablet or powder – sink conditions). Max solvent volume: 900 ml 
Temperatures 25-50 °C 
Stirring rates 50 or 100 RPM 
Result Reported as a curve showing concentration over time (min) 
  • Evaluating the developability of a compound: Does the dose at the given particle size dissolve in vivo? This can be tested by examining the dissolution rate in different buffer solutions mimicking the physiological conditions (pH 1-8, Fessif, Fassif) 

Let’s Help!

Dr. Fozia Shah, Project Manager

OR

Consult our Experts

Dr. Wenbo Wang
QC Chemist

Dr. Anna Shevchenko
Principal Scientist

Literature

Abdou HM (1989) Dissolution, bioavailability & bioequivalence. Mack Publishing Co 

Hanson WA (1982) Handbook of dissolution testing. Pharmaceutical Technology 

Hintz RJ, Johnson KC (1989) The effect of particle size distribution on dissolution rate and oral absorption. International Journal of Pharmaceutics 51(1):9-17 

Rasenack N, Müller BW (2002) Dissolution rate enhancement by in situ micronisation of poorly water-soluble drugs. Pharmaceutical research 19(12):1894-1900  

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