Dissolution rate measurements

Slide

The dissolution rate is a measure of the actual release rate of the compound at the given particle size etc. in an aqueous media. It often¬†varies¬†considerably with solid form, e.g. particle size and shape (read more about dissolution theory).‚ÄĮThe rate of dissolution‚ÄĮis of major importance in regard to the¬†behaviour¬†of the compound‚ÄĮin vivo.‚ÄĮ¬†

Dissolution tests‚ÄĮare used for:¬†

  • Ensuring that production processes are under control¬†
  • Formulation development: comparison of effect of different formulation on product performance¬†
  • Evaluation of the effect of different particle size batches on the dissolution¬†

For Material experts: 

Instrument and measuring principle 

The dissolution test equipment applied by Particle Analytical is a Vankel Dissolution Sampling Station. The concentrations are determined on a Varian UV-VIS spectrometer. The‚ÄĮdefault solvent volume is 900 ml unless otherwise stated. The apparatus is equipped with a¬†fibre¬†optic sensor.¬†

WHAT TYPE OF APPARATUS 

Instrument Vankel VK7000 /Versa Fiber optics 
USP/Ph. Eur. USP „Äą711„ÄČ /Ph.Eur. 2.9.3 (non-GMP)
Sample amount Depends on purpose (dissolution of tablet or powder ‚Äď sink conditions). Max solvent volume: 900 ml 
Temperatures 25-50 ¬įC 
Stirring rates 50 or 100 RPM 
Result Reported as a curve showing concentration over time (min) 
  • Evaluating the developability of a compound: Does the‚ÄĮdose at the given particle size dissolve in vivo? This can be¬†tested by examining the dissolution rate in¬†different buffer solutions¬†mimicking the¬†physiological conditions¬†(pH 1-8, Fessif, Fassif)¬†

Let’s Help!

Dr. Fozia Shah, Project Manager

OR

Consult our Experts

 

Dr. Changyong Lu
QC Chemist


Dr. Anna Shevchenko
Principal Scientist

Literature

Abdou HM (1989) Dissolution, bioavailability & bioequivalence. Mack Publishing Co 

Hanson WA (1982) Handbook of dissolution testing. Pharmaceutical Technology 

Hintz RJ, Johnson KC (1989) The effect of particle size distribution on dissolution rate and oral absorption. International Journal of Pharmaceutics 51(1):9-17 

Rasenack N, M√ľller BW (2002) Dissolution rate enhancement by in situ micronisation of poorly water-soluble drugs. Pharmaceutical research 19(12):1894-1900¬†¬†

Scroll to Top