Introduction to FTIR
In Fourier transform infrared spectroscopy (FTIR), infrared radiation is passed through a sample. The resulting spectrum represents the molecular absorption, creating a molecular fingerprint of the sample.
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The primary uses of (FTIR) are:
- Identification of API as a routine analysis
- Identification of impurities
- Quantification of components in mixtures, for instance determination of content of amorphous material in a crystalline sample (percent crystallinity).
- Examination of changes in the solid state due to interactions with excipients – i.e. compatibility studies in order to chose the most stable excipients for the final product.
Instrument and measuring principles, FTIR
|Instrument||Spectrum One from Perkin Elmer with SPECAC Golden Gate ATR unit|
|Sample amount||1-5 mg|
|Result||FTIR generates absorption or transmission spectra as a function of wavenumbers. Measuring range: 4000-500 cm-1|