We offer you free consulting in issues concerning particles characterisation. It might be questions regarding particle behaviour in relation to manufacturing – or it might be advise on necessary experiments to clarify stability. Do not hesitate to send us an email and we will get back to you shortly.
Furthermore, if you are able to gather 10-15 people, we would be happy to come by your company and give an introdution into our field of expertise. We suggest following three talks – with a duration of approximately two hours:
- Solid state characterization is essential in order to understand and control a compound during development. Lack of control of the particles increases the risk of sudden transformations, leading to changes in the stability and properties of the compound. Such changes might have large consequences for the behavior of the compound during manufacturing and -ultimately- in vivo. I.e. the potential risk, if these analyses are not performed, is that the analytical program and the clinical studies have to be repeated, which of course is quite costly.
- Most solid materials are capable of forming different crystalline structures, known as polymorphic forms. These polymorphic forms have different physicochemical properties that might have significant impact on the intended use of the material. It is of immense importance to determine the crystal form in order to minimize the risk of transformation into other forms during development or, even worse, after introduction to the market. We present a rational approach to meet this risk.
- Particle size and shape are often critical parameters in the manufacture of many products. The goal of all particle-sizing techniques is to provide a single number that is indicative of the particle size. However, particles are three-dimensional objects for which at least three parameters (length, breadth and height) are required in order to provide a complete description. Thus, measurement of particle size is not an exact technique and a “true” value does not exist. A range of analytical techniques is available; these all have their strengths and weaknesses. Some examples of pitfalls in particle analysis will be given.