Hygroscopicity

Hygroscopicity plays a crucial role for development of a new drug candidate. This property must be included in the developability evaluation scope during preformulation. If your material deliquesces by moisture at normal relative humidity ranges is it worth to take it forward?

Do you need to:

• Evaluate the moisture uptake by your pharmaceutical powder?
• Study the reversibility of the moisture uptake?
• Evaluate the mass loss on drying?
• Study hydrate – anhydrate transitions?
• Investigate the crystallization of amorphous material induced by moisture?
• Calculate BET and GAB etc. parameters calculated from water sorption-desorption isotherms?
• Measure the specific surface area of your powder by organic vapor sorption?

Read more about Dynamic Vapor Sorption.